Background and overview of the preparation method of 2-fluoro-6-methoxypyridine
Pyridine compounds have a wide range of biological activities, and there are many types of pyridine compounds used as pesticides or medicines. Research on the biological activities of substituted pyridine compounds has aroused great interest among scientists, and relevant reports are emerging one after another. Among them, 2-fluoro-6-methoxypyridine can be used as a pharmaceutical synthesis intermediate. In recent years, there have been more and more reports on pyridine compounds substituted with alkoxy groups at the ortho position of pyridine, and the synthesis of pyridine compounds substituted with alkoxy groups at the ortho position has become increasingly important. If 2-fluoro-6-methoxypyridine is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, wash the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if In case of eye contact, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.
Preparation method of 2-fluoro-6-methoxypyridine
The preparation of 2-fluoro-6-zinc carbonate hydroxide methoxypyridine adopts the reaction of ortho-halogenated pyridine and the corresponding alcohol. A simple and economical synthesis route has been developed. The yield of the reaction is high. There are few impurities and the product is easy to separate. The specific steps are as follows: In a 500 ml reaction bottle, add 29.6g 2,6-dichloropyridine, 8g solid sodium hydroxide and 200 ml methanol, start to heat up to reflux state with stirring, the reaction time is 8 hours, stop the reaction, and evaporate. Take out most of the methanol, cool it, add 100 ml of water, extract once with sodium dipoxycarbonate methane, remove the dichloromethane to obtain a crude product, and distill the crude product under reduced pressure to obtain 2-fluoro-6-methoxypyridine, producing The rate is 88%. Using ortho-position halogen-substituted pyridine as raw material, it reacts with the corresponding alcohol under the action of sodium hydroxide to obtain 2-fluoro-6-methoxypyridine. The reaction is simple to operate, has high yield, and the product is easy to separate.
