Background and overview of application examples of 4-(methanesulfonyl)phenylboronic acid
4-(Methanesulfonyl)phenylboronic acid is a boric acid derivative. Boric acid compounds can undergo Suzuki reactions with chlorine, bromine or iodinated aromatics and alkenes, thereby connecting a variety of groups, and the downstream products are very rich.
Application examples of 4-(methanesulfonyl)phenylboronic acid
Application examples of 4-(methanesulfonyl)phenylboronic acid Application 1.
4-(Methanesulfonyl)phenylboronic acid can be used to prepare compounds with the following multi-substituted vinyl structures. Substituted vinyl compounds are widely found in natural products, active pharmaceutical intermediates and luminescent materials. Among them, polyaryl-substituted vinyl skeletons have been widely studied due to their aggregation-induced emission (AIE) effect.
Application examples of 4-(methanesulfonyl)phenylboronic acid Application 2.
Substituted thiophene compounds can be used to prepare compounds with the following substituted thiophene structures. ERRα is highly relevant in the treatment of tumors and other related diseases (osteoporosis, diabetes, etc.). The compounds are used as estrogen receptor-related receptor (ERR) inverse agonists, especially estrogen receptor-related receptor α (ERRα) inverse agonists, and are used in the preparation of prevention, improvement, treatment, and ERRα activity It has important uses in medicines for mediated diseases.
Application examples of 4-(methanesulfonyl)phenylboronic acid Application 3.
4-(Methanesulfonyl)phenylboronic acid can also be used to prepare compounds with the following boronic acid-10B structure for preventing and/or treating cancer. This compound is a BRG1 inhibitor. BRG1 was recently identified as a gene frequently mutated in neuroblastoma zinc tube tumors, whereby targeted therapy against the BRM protein may be applicable to the treatment of various cancers.
References
[1] [Chinese invention] CN201910485350.4 Multi-substituted vinyl compounds, their preparation methods and applications
[2] [Chinese invention] CN201910576438.7 Substituted thiophene compounds, their preparation methods and their uses
[3] [Chinese invention] CN201910357130.3 A compound for preventing and/or treating cancer and its preparation method and application
