Background and overview[1][2]
1-(4-Chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol, also known as 1 -(4-chlorophenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-4,4-dimethylpentan-3-ol, tebuconazole. Tebuconazole is a broad-spectrum triazole fungicide whose mechanism of action is a sterol demethylation inhibitor. Seed treatment or foliar spraying can prevent and control various diseases such as rust, powdery mildew, and smut of cereal crops. However, the use of this fungicide in seed dressing or in the seedling stage can easily cause an inhibitory effect on the growth of cereal crops, especially on corn seedlings. Continuous single use can easily lead to drug resistance and the cost of single use is high. As a seed agent, tebuconazole can completely prevent and control barley loose smut, wheat net smut, light smut and seed-borne ring spot. It is widely used in Europe, North and South America, and its global sales have exceeded US$500 million in recent years. It is a pesticide variety with good development prospects.
Preparation[2]
CN200810101939.1 provides a preparation method of tebuconazole aqueous emulsion. The weight percentage of each component in the formula is: tebuconazole 1-25%, emulsifier 1-20%, antifreeze 1-5%, defoaming agent 0-2%, solvent 1-45%, thickener 0.1-3%, the rest is water. The emulsifier is selected from NPE, AEO, 100#, 300#, 500#, 600#, 700#, BY (or EL), 2000#, 1600#, Osmo T, 600#+P2O5→phosphate ester salt, NPE+P2O5→One or more of phosphate ester salt and Ci-acid ester.
The antifreeze agent is selected from one or more types of ethylene glycol, glycerol, isopropyl alcohol, and butanol. The defoaming agent is selected from silicone. The solvent is selected from one or more of methanol, ethanol, cyclohexanone, N-methylpyrrolidone, aromatic hydrocarbons or their complexes. The thickener is selected from one or more of magnesium aluminum silicate, CMC, sodium alginate, PVA, arabic acid gum, polyacrylic acid, and xanthan gum. The manufacturing process of the tebuconazole bactericidal aqueous emulsion is: take the raw materials with the above weight percentage, dissolve the tebuconazole with a small amount of solvent and surfactant, stir evenly to obtain a uniform oil phase; then mix water, defoaming agent, antifreeze Stir and mix the agent and thickener to form a homogeneous water phase. Add the oil phase to the water phase or the water phase to the oil phase under room temperature and high-speed stirring to form a well-dispersed water emulsion. Measure it with a particle size distribution tester. The average particle size of the product is less than 20.00 microns; the stirring speed selected in the present invention is 200 rpm-1700 rpm; the stirring time is 30-60 minutes. Compared with the prior art, the tebuconazole aqueous emulsion of the present invention has the following advantages: 1. Since it does not contain toxic and flammable organic solvents, there is no danger of fire and explosion, no unpleasant toxic odor, little eye irritation, and reduced It reduces environmental pollution and greatly improves the safety of production, storage, transportation and users; 2. Using cheap water of PVC resin as the base, the manufacturing cost is reduced to varying degrees; 3. The amount of emulsifier used is equivalent to that of emulsified oil, However, a large amount of organic solvents are saved, and the cost of the preparation is greatly reduced; 4. The requirements for packaging containers are far less stringent than that of emulsifiable concentrate, which can reduce packaging costs.
Apply [3]
Used in the preparation of pesticides. CN201010187034.8 provides a pesticide composition composed of the systemic fungicide tebuconazole, the protective fungicide mancozeb, a wet spreading agent and other auxiliaries, which can improve the resistance to dormant sporangia of corn brown spot pathogen The germination inhibitory activity and field disease control effect can reduce the usage of tebuconazole, improve the safety of corn seedlings, reduce the use cost, and apply the composition for seed treatment and field spray treatment to prevent and control corn brown spot and other diseases. method.
The present invention found that the combination of tebuconazole and mancozeb in the ratio of 4:1 to 1:4 has a significant synergistic effect on the germination of dormant sporangia of Xanthomonas spp. This composition may contain 10% to 40% of tebuconazole, 10% to 40% of mancozeb, 1% to 2% of sodium methylene dinaphthalene sulfonate as dispersant; calcium dodecylbenzene sulfonate and Alkylphenol polyoxyethylene ether formaldehyde compound composite wet spreader 5% to 10%, kaolin 8% to 74%. The results of the joint toxicity determination of the ratio of tebuconazole and mancozeb to the dormant sporangia of the brown spot pathogen in the present invention are shown in:��1. The results in Table 1 prove that the co-toxic coefficient (CTC) values of the combination of tebuconazole and mancozeb in the ratio of 4:1 to 1:4 are greater than 120. According to the Agricultural Industry Standard of the People’s Republic of China (NY /T1156.6-2006) determined that the mixed use of the two has a synergistic effect, significantly improving the inhibitory activity against the germination of dormant sporangia of the brown spot pathogen, and the synergistic effect is significant. In the present invention, the composition of tebuconazole and mancozeb in a ratio of 4:1 to 1:4 reduces the content of tebuconazole compared with the use of tebuconazole alone, and seed treatment or foliar spraying improves the effectiveness of corn seedlings. It is safe, reduces the cost of use, and the two agents have different mechanisms of action and complementary disease prevention mechanisms, which can delay the shortcomings of continuous single use of tebuconazole, such as the easy development of drug resistance. Table 1 Tebuconazole and maneb polyurethane raw materials zinc and their different ratios inhibit the germination of dormant sporangia of corn brown spot (25°C).
Main reference materials
[1] CN201010187034.8 A pesticide composition for controlling corn brown spot disease
[2] CN201611215656.0 A preparation method for converting tebuconazole isomers into tebuconazole alcohol
[3] CN200810101939.1 Preparation method of tebuconazole aqueous emulsion
