Overview[1]
Phospholipids are an important component of biological membranes, basic substances of life, and active components of all biological cells. They play an important role in cell penetration and metabolism. Hydrogenated lecithin is a stable emulsifier and moisturizer formed by hydrogenating lecithin under the action of a catalyst. The stability and emulsifying properties of hydrogenated lecithin are improved and it is widely used in food, medicine, cosmetics, etc. in the industry. Hydrogenated lecithin has strong hydrophilicity and moisturizing properties, and has a strong affinity for the skin and mucous membranes. It can be used in cosmetic formulas to moisturize, emulsify and disperse, and condition the skin.
Hydrogenated lecithin has strong hydrophilicity and moisturizing properties, and has a strong affinity for the skin and mucous membranes. It can be used in cosmetic formulas to moisturize, emulsify, disperse, and resist oxidation; as a surfactant It can also condition the skin to achieve a good oil-water balance effect and better absorb nutrients. In shampoos and liquid detergents, hydrogenated lecithin acts as a pearlescent agent. Hydrogenated lecithin can also be used to develop skin care products. Cream, hand cream, lip balm, sunscreen oil and other high-end cosmetic products.
Apply[3]
Preparation method of submicron emulsion with improved efficacy:
A: Weigh the white pond flower seed oil, Cabot silica acid, and sheath according to the mass ratio of 5~10:3~5:5~10:1~3:0.3~0.5:10~20 Ceramide III synthesized from aminoalcohol and oleic acid, sugars, catalysts, and deionized water are put into a stainless steel reactor as the reaction base material;
B: Fill the stainless steel reactor with nitrogen for protection. The temperature in the stainless steel reactor is controlled at 120℃~140℃, the pressure is 1.2~1.8kgf/cm2, and the reaction time is 2~4 hours; it is maintained during the reaction. 15rpm speed, scrape and stir;
C: Take a small amount of the reactant product and analyze it by chromatography. The mass fraction of ultra-long carbon chain ceramide containing behenic acid group in the reaction product is higher than 2%, and the mass fraction of glycosylceramide is higher than 1%, the reaction is considered complete; then lower the temperature in the stainless steel reactor to 75~90°C and the pressure to normal pressure;
D: Add hydrogenated lysolecithin with a mass ratio of 1.0~3 diluent.0:100 to the reaction product, and cholesterol with a mass ratio of 3.0~5.0:100 to the reaction product, with a mass ratio of 5.0~10.0: 100 deionized water, maintain the temperature in the stainless steel reactor at 75~90°C, stir with a stirrer at 15rpm for 0.5~1 hour to form a uniform emulsion;
E: Use a high-pressure homogenizer to homogenize the emulsion obtained in step D three times at 75~90°C and 1500~2500bar pressure, and then cool it to room temperature to obtain a subcutaneous agent that has the effect of improving atopic dermatitis. Micron emulsion.
The submicron emulsion prepared by this method, which has an effect of improving atopic dermatitis, contains unreacted ceramide III synthesized from sphingosine and oleic acid, sugar components and behenic acid, as well as white pond flower seed oil, It also contains reaction products, namely ultra-long chain ceramide containing behenic acid groups generated through transesterification reaction, and glycosylceramide components generated through esterification reaction. Finally, cholesterol and hydrogenated lysolecithin are added as emulsifiers. Form an emulsion with deionized water and homogenize it through a high-pressure homogenizer to form a nano-lipid particle emulsion encapsulated by cholesterol and hydrogenated lysolecithin. The average particle size of the nano-lipid particles in the obtained nano-lipid particle emulsion is 100 ~350nm.
Preparation[2]
Hydrogenated lecithin is a stable emulsifier formed by hydrogenating lecithin under the action of a catalyst. It retains the active ingredients of lecithin intact. Yu Dianyu and others used supercritical technology to carry out the addition reaction of hydrogenated lecithin in the supercritical CO2 state, using Pd/C as a catalyst. Song Lan et al. used the impregnation method to prepare Pd/C catalysts. They used the change in iodine value before and after the hydrogenation reaction of soybean lecithin as an indicator to examine the impact of preparation conditions on Pd/C activity, and analyzed it with the help of transmission electron microscopy (TEM) characterization methods. Catalyst morphology changes.
