Application and preparation background and overview of 5-bromo-3-methylpyridine-2-carboxylic acid
5-Bromo-3-methylpyridine-2-carboxylic acid, density 1.692g/cm3, boiling point 330.5ºC at 760 mmHg, flash point 153.7ºC, refractive index 1.602. 5-Bromo-3-methylpyridine-2 -Formic acid can be used as an intermediate in pharmaceutical and chemical synthesis. If 5-bromo-3-picoline-2-carboxylic acid is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and rinse the skin thoroughly with soap and water. If discomfort occurs, Seek medical attention; if eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately. Advice to protect rescuers is as follows: Move the patient to a safe place, consult a doctor, and if conditions permit, please show this chemical safety data sheet to the doctor who comes to the scene. If there is a small leak, collect the leaked liquid in a sealable container as much as possible, absorb it with sand, activated carbon or other inert materials, and transfer it to a safe place. Do not flush it into the sewer; if there is a large leak, Build an embankment or dig a pit to contain it, seal the drainage pipe, cover it with foam to inhibit evaporation, use an explosion-proof pump to transfer it to a tank truck with benzene boric acid or a special collector, and recycle or transport it to a waste treatment site for disposal.
Application and preparation structure of 5-bromo-3-methylpyridine-2-carboxylic acid
Applications and preparation of 5-bromo-3-methylpyridine-2-carboxylic acid
5-Bromo-3-methylpyridine-2-carboxylic acid can be used as an intermediate for pharmaceutical and chemical synthesis, such as dimethyl dimethyl 5-bromo-3-methylpyridine-2-carboxylic acid (450mg, 2.08mmol) Potassium carbonate (862 mg, 6.24 mmol) and methyl iodide (739 mg, 5.21 mmol) were added to the formamide (2 mL) solution. The reaction was stirred at 80°C for 40 minutes. The reaction mixture was partitioned between ethyl acetate and water, and the organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated to give the acetylated product as a yellow solid (380 mg, 82%). The acetylated product can then further participate in reactions to prepare other substances with certain active properties.
Application and preparation of 5-bromo-3-methylpyridine-2-carboxylic acid [1]
To a suspension of 5-bromo-3-methylpyridine-2-carbonitrile (1.22 g, 7.21 mmol) in ethanol (10 mL) was added 6 N sodium hydroxide (5 mL) and the reaction mixture was heated at80 ℃Stir for 1.5 hours. The organics were concentrated and the reaction mixture was diluted with water and partitioned between ethyl acetate. Acidify the aqueous phase to pH 2-3. The product was extracted with ethyl acetate, washed with brine, dried over sodium sulfate, filtered and concentrated to give the product as a yellow solid 5-bromo-3-methylpyridine-2-carboxylic acid (185 mg, 98%).
