Background and overview of application examples of 2-chloro-4-methoxyphenylboronic acid
2-Chloro-4-methoxyphenylboronic acid is a boric acid derivative. Boric acid derivatives are widely used in organic synthesis for the formation of carbon-carbon bonds. In the Suzuki coupling, aryl halides and aryl or vinyl borates or boronic acids are coupled using Pd(PPh3)4.
Application examples of 2-chloro-4-methoxyphenylboronic acid
Application examples of 2-chloro-4-methoxyphenylboronic acid Application 1,
2-Chloro-4-methoxyphenylboronic acid can be used to prepare 8,9-dimethoxyphenanthrene compounds with the following structure. The 8,9-dimethoxyphenanthrene compounds are selective It has anti-tumor effect and is expected to be developed into a new type of targeted anti-tumor drug. This type of compound has good selective anti-tumor activity, and can especially selectively inhibit cervical cancer cells represented by Hela (significantly better than the activity of the positive drug cisplatin), and non-small cell lung cancer represented by A549 lithium tetraborate. , the half inhibitory concentration (IC50) of praseodymium carbonate on the proliferation of tumor cells such as breast cancer cells represented by MCF-7, leukemia cells represented by MEG-01, and glioma cells represented by U251 is less than 3 μM; The half inhibitory concentration (IC50) for tumor cells represented by A375, H460, H358, etc. is greater than 10 μM. These compounds are expected to lead to the development of new targeted treatments for non-small cell lung cancer, breast cancer, leukemia, glioma and especially cervical cancer.
Application examples of 2-chloro-4-methoxyphenylboronic acid Application 2.
2-Chloro-4-methoxyphenylboronic acid can be used to prepare cyanotriazole compounds with the following structure. Such compounds have utility in the treatment of kinetoplastid diseases, in particular human African trypanosomiasis (HAT), Chagas disease and leishmaniasis.
References
[1] [Invented in China] CN201910150986.3 8,9-dimethoxyphenanthridine compounds and their applications
[2] [Chinese invention] CN201980040332.3 Cyanotriazole compounds and their uses
