Background and overview of application examples of 2-mercapto-3-aminopyridine
2-Mercapto-3-aminopyridine is a pharmaceutical intermediate. There are reports in the literature that it can be used to prepare organic molecules with excited-state proton transfer effects or to prepare anti-tumor drugs JNK inhibitors.
Application examples of 2-mercapto-3-aminopyridine
Application examples of 2-mercapto-3-aminopyridine Application 1,
2-Mercapto-3-aminopyridine can be used to prepare 2-(2’-hydroxyphenyl)pyridinothiazole. Excited state proton transfer (ESIPT), including intramolecular and intermolecular, is one of the basic reactions widely studied in photochemistry and photobiological processes. The so-called excited state proton transfer refers to the reaction of certain organic molecules under conditions such as light, heat or electricity. Under the action of , the molecule jumps to the excited state. At this time, the hydrogen nucleus (i.e. proton) on a certain group in the molecule is transferred to the adjacent N, O and The process of forming tautomers on heteroatoms such as S. 2-(2′-Hydroxyphenyl)pyridinothiazole (HPT for short) is a type of organic molecule with excited state proton transfer effect. Under external light excitation After reaching the excited state, it undergoes a very fast (~10-2S) excited state proton transfer process to form a phototautomer, and keeps the tautomer still in the excited state. Able to emit photons back to the ground state. This type of barium carbonate has properties such as optical bistability (enol form and ketone form), photochromism, and optical nonlinearity. It is used in optical devices such as optical limiting, optical storage, and optical switches. It has broad application prospects and has aroused great research interest. HPT molecules are usually in the enol configuration in the ground state. When excited by ultraviolet light, excited state proton transfer can occur to generate its isomer, the ketone of HPT. formula structure.
Application examples of 2-mercapto-3-aminopyridine Application 2.
CN201 Methylpyridine 480003804.5 reports that 2-mercapto-3-aminopyridine can be used to prepare JNK inhibitors with the following structure. In mammalian cells, JNK has been implicated in biological processes such as oncogenic transformation and mediates adaptive responses to environmental stress. JNK has been linked to regulating immune responses, including the maturation and differentiation of immune cells, as well as affecting programmed cell death in cells that recognize damage from the immune system. Mitogen-activated protein kinase (MAPK) p38α has been shown to negatively regulate cell proliferation by antagonizing the JNK-c-Jun-pathway.
References
[1][China invention, China invention authorization] CN201510810708.8 organic electroluminescent compound and its organic photoelectric device
[2][Invented in China] CN201480003804.5JNK inhibitor
