Application background and overview of 4-cyclohexylbenzeneboronic acid
4-Cyclohexylphenylboronic acid is an organic intermediate that can be used in Suzuki coupling reactions and can be used to prepare organic electroluminescent (OLED) materials. 4-Cyclohexylphenylboronic acid can also be used as a pharmaceutical intermediate for the preparation of sartanbiphenyl derivatives.
Applications of 4-cyclohexylbenzeneboronic acid
Application report of 4-cyclohexylbenzeneboronic acid 1.
CN201911193208.9 reported the preparation of 4-cyclohexylphenylboronic acid as an OLED host material that is not easy to quench and crystallize and has good film-forming properties.
In a 1-liter three-necked flask, equipped with magnetic stirring, after nitrogen replacement, add 40.07g sodium carbonate (0.378mol), 42.84g (4-cyclohexylphenyl)boric acid (purity 99%, 0.21mol) and 100ml toluene in sequence. After nitrogen replacement again, 0.5g Pd132 was added in sequence. After adding, heat to 80°C. Begin to add dropwise to a solution consisting of 47.2g of raw material (purity 99%, 0.1mol) and 100ml of toluene, and control the temperature to 75-90°C. Cool to room temperature, add 100 ml of deionized water for hydrolysis, stir for 10 minutes, filter, boil and wash the filter cake with DMF several times, and filter to obtain 47.84 g of light yellow solid with a purity of 99% and a yield of 80%.
Product MS (m/e): 630; elemental analysis (C44H38S2): theoretical value C: 83.76%; H: 6.07%; S: 10.16%; measured value C: 83.75%; H: 6.08%; S: 10.16%.
Applications of 4-cyclohexylbenzeneboronic acid 2.
CN201710979110.0 reported that 4-cyclohexylphenylboronic acid can be used to prepare a sartanbiphenyl derivative. Sartan drugs are highly efficient, long-acting, safe, can be taken orally, are well tolerated, and can protect target organs. They can avoid the adverse reactions of cough caused by non-selective ACEI drugs. They have obvious advantages and continue to occupy the market. Improved, chlorofenboric acid has become one of the most promising antihypertensive drugs on the market in the 21st century. Most sartan drugs use sartanbiphenyl as their key intermediate.
References
[1] [Chinese invention] CN201911193208.9 An OLED material and its application
[2] [Invented in China] CN201710979110.0 A synthesis method of sartanbiphenyl and its derivatives
