Application background and overview of 5-chloro-2-fluoropyridine
5-Chloro-2-fluoropyridine can be used as an intermediate for pharmaceutical and chemical synthesis. If 5-chloro-2-fluoropyridine is inhaled, move the patient to fresh air; if the skin comes into contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical treatment if you feel uncomfortable; if the eyes are clear In case of contact, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.
Applications of 5-chloro-2-fluoropyridine
5-Chloro-2-fluoropyridine can be used as an intermediate for pharmaceutical and chemical synthesis. Examples of its application are as follows:
Applications of 5-chloro-2-fluoropyridine 1. It can be used to prepare a modified activated carbon adsorbent with adsorption properties for orthophosphate in water.
After cleaning the activated carbon, it is modified with a mixture of 3-bromo-4-fluoronitrobenzene and 5-chloro-2-fluoropyridine to prepare substance C; substance C is treated with NbCl4 , InCl3, Sr(NO3)2, Mn(NO3)2 sub>The prepared mixed solution was modified to prepare substance D; substance D was treated with 3-bromo-2-fluorotoluene, 1-bromo-2-iodotetrafluoroethane, 3-chlorothiophene-2-carboxylic acid methyl ester, 2 The mixed liquid prepared from -hydroxy-3-pyrazinecarboxylic acid methyl ester was modified to prepare substance F; substance F was treated with nitrobenzene borate PbCl2, CuCl2, The substance obtained after modification of the mixed solution prepared by Co(NO3)2 and Mg(NO3)2 is the substance in the water body. Orthophosphate is a modified activated carbon adsorbent with adsorption properties.
Applications of 5-chloro-2-fluoropyridine 2. For the preparation of methyl 2-[1-(5-chloropyridin-2-yl)piperidin-4-yl]acetate.
The specific steps are: combine 5-chloro-2-fluoropyridine (500mg, 3.80mmol), DIEA (1.5g, 11.61mmol), methyl 2-(piperidin-4-yl)acetate (599mg, 3.81mmol) ) solution dissolved in DMSO, stirred at 90°C for 16 hours under N2. The resulting solution was extracted with 2×50 mL EtOAc, and the combined organic layers were concentrated in vacuo and purified by silica gel chromatography using EtOAc/hexane (1/1) to afford 700 mg (69%) of the title compound as a white solid over sodium carbonate. MS (ES, m/z): 268.9
