Application overview of bis-norbornadiene-rhodium tetrafluoroborate
Bis-norbornadiene-rhodium(I) tetrafluoroborate can be used as a catalyst for organic synthesis reactions.
Applications of bis-norbornadiene-rhodium tetrafluoroborate
Application examples of bis-norbornadiene-rhodium(I) tetrafluoroborate are as follows:
1) Preparing an asymmetric hydrogenation method for fluorine-containing enamine compounds, including the following steps: under anhydrous and oxygen-free conditions, dissolve a rhodium catalyst with a molar ratio of 1:0.8 to 1.2 and a chiral ligand. In solvent A, stir and react at 20°C to 40°C for 0.5 to 2 hours to obtain an in-situ catalyst; the in-situ catalyst does not separately separate calcium tetraborate, and directly adds enamine compounds and solvent B to form a reaction system; Place the reaction system in a high-pressure reactor, stir and react for 2 to 24 hours under conditions of 0 to 50°C and 2 to 50 atmH2; the above-mentioned rhodium catalyst is di(1,5-cyclooctadiene)rhodium tetrafluoroborate or bis-norbornadiene-rhodium(I) tetrafluoroborate.
2) For preparing a kind of 3-hydroxymethyltetrahydrofuran, the following steps are: 1) Hydroformylation reaction: using 2 dimethyl sulfoxide and 5-dihydrofuran as raw materials, reacting with Rh catalyst The hydroformylation reaction catalyzed by the complexation of the precursor and the organic phosphine ligand generates tetrahydrofuran-3-carboxaldehyde; 2) Hydroboration reduction reaction: The obtained tetrahydrofuran-3-carboxaldehyde in step 1) is reduced by metal borohydride to generate 3 -Hydroxymethyltetrahydrofuran. The Rh catalyst precursor described in step 1) is rhodium dicarbonyl acetylacetonate, dicarbonyl rhodium monochloride dimer, bis-norbornadiene-rhodium (I) tetrafluoroborate or bis(1,5-cyclooctadiene rhodium chloride), the organic phosphine ligand is one of tris(2,4,6-trimethylphenyl)phosphine, tri-o-tolylphosphine or triphenylphosphine.
