Application background and overview of isopropyl glycidyl ether
Isopropyl glycidyl ether can be used as a pharmaceutical synthesis intermediate. If isopropyl glycidyl ether is inhaled, please move the patient to fresh air; if the skin comes in contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical treatment if you feel uncomfortable; if in contact with the eyes, The eyelids should be separated, rinsed with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.
Application and preparation of isopropyl glycidyl ether
Synthesis of 2-(ethylene oxide-2-ylmethoxy)propane (isopropyl glycidyl ether). To a solution of 60% NaH (0.18 g, 4.5 mmol) in DMF (10 ml) cooled to 0°C, a solution of 2-propanol (0.5 g, 3.73 mmol) in DMF (2 ml) was added dropwise. After stirring for 30 minutes, a solution of epibromohydrin (1.11 g, 8.18 mmol) in DMF (1 ml) was added dropwise. The reaction was allowed to warm to room temperature and stirred for 48 hours. The solvent was removed in vacuo and the residue was purified using preparative TLC (30:1, DCM:MeOH) to give compound 6C. 2-(Ethylene oxide-2-ylmethoxy)propane (isopropyl glycidyl sodium bicarbonate oil ether).
Applications of isopropyl glycidyl ether
Isopropyl glycidyl ether can be used to synthesize N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indane-2-oxypropyl)piperazine Acetamide, the structure is as follows:
The specific steps are as follows: Add 5C (0.405g, 1.64mmol) to a solution of isopropyl glycidyl ether (0.43g, 2.3mmol) in ethanol (4ml). The solution was heated to reflux and stirred for 24 hours. Upon completion, the solution was concentrated in vacuo and purified using preparative TLC (10 rubidium tetrafluoroborate: 1, DCM: MeOH) to give N-(2,6-dimethylphenyl)-2-[4-(2- Hydroxy-3-indan-2-oxypropyl)piperazinyl]acetamide. Mass spectrum (M+1)=438.36.
