Background and overview[1][2]
3,5-Dimethylanisole is an ether organic compound that can be used as an organic intermediate. It can be prepared from 3,5-dimethylphenol to ether in one step.
Preparation[1]
Preparation of 3,5-dimethylanisole:
3,5-xylenol (10g, 0.082mol) and anhydrous potassium carbonate (34g, 0.25mol) were added to DMF (150ml), and methyl iodide (12.8g, 0.090mol) was added dropwise in an ice bath at room temperature. Stir overnight. After the reaction was completed, water was added and extracted with ethyl acetate. The organic phase obtained by extraction was washed with saturated brine, dried, evaporated under reduced pressure, and 10 g (90%) of the product was obtained by column chromatography. 1HNMR (MHz, d-CDCl3), δ6.60 (s, 1H), 6.53 (s, 2H), 3.77 (s, 3H), 2.29 (s, 6H).
Apply[2]
CN201110058073.2 discloses a method for synthesizing 6’-diethylamino-1’3’-dimethylbenzofuran, a thermal pressure-sensitive chromogenic material. Benzofuran compounds are a widely used heat-pressure-sensitive chromogenic material. These compounds usually do not develop color. They develop color after being heated and pressed together with a color developer. Different resonance structures show different colors. This method is to dissolve 2-(2-hydroxy-4-diethylaminobenzoyl)benzoic acid and 3,5-dimethylphenol or 3,5-dimethylanisole in a dehydrating strong acid, such as concentrated Condensation and hydrolysis in sulfuric acid, fuming sulfide, phosphoric acid, polyphosphoric acid and acetic anhydride, then in the presence of solvent, use strong alkali such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate to make it alkaline, and heat to close the loop The thermal pressure-sensitive chromogenic material is then generated. The synthesis method is simple and convenient, the raw materials are easily available, and the color of the obtained finished product is stable, and it is widely used in fields such as thermal pressure-sensitive paper, color-changing coatings, and color-changing clothing.
Main reference materials
[1] [China invention, China invention authorization] CN201210202059.X Deuterated benzopyran compounds and their applications
[2] CN201110058073.2 A kind of synthesis method of orange thermal pressure sensitive discoloration material
