Application background and overview of bis(pyridine-2-carboxylic acid)vanadium(IV)
Bis(pyridine-2-carboxylic acid) vanadyl(IV) is also called bis(pyridine-2-carboxylic acid) vanadyl and picolinate vanadyl. Bis(pyridine-2-carboxylic acid) vanadyl(IV) has medicinal uses, and there are reports in the literature that it can be used to prepare drugs for preventing and treating neurodegenerative disease Alzheimer’s disease and capsules for diabetic patients.
Applications of bis(pyridine-2-carboxylic acid) vanadyl(IV)
Application report 1 of bis(pyridine-2-carboxylic acid)vanadium(IV)
CN201611231409.X provides a coniferous aldehyde or coniferous aldehyde and vanadium compound composition for preventing and treating neurodegenerative diseases. The invention uses coniferous aldehyde or a pharmaceutical composition combined with coniferous aldehyde and a vanadium compound as raw materials to prepare drugs for preventing and treating Alzheimer’s disease, a neurodegenerative disease. As a further improvement of the present invention, the potassium trifluoroborate vanadium compound includes inorganic vanadium compounds and organic vanadium compounds. The inorganic vanadium compounds include vanadium oxo complexes, peroxo vanadium complexes, hydroxylamine vanadium complexes, and vanadium heteropolymers. Acid complex; the organic vanadium compound includes vanadyl benzoate, aspirin vanadyl, acetylacetonate vanadyl, bis(2-methyl-3-hydroxy-4-pyrone) vanadyl (BMOV), 3-hydroxyl -2-ethyl-4-pyrone (BEOV), 3-hydroxy-2-isopropyl-4-pyrone (BIOV), 3-hydroxy-2-n-butyl-4-pyrone ( BnBOV), bis(pyridine-2-carboxylic acid) vanadyl(IV) (VO(Pa)2), vanadyl picolinate (VO-DPA), phthalamine picolinate (VO-PAM), picolidine Vanadyl formate (VO-MPA), vanadyl picolinate (VO-PA), vanadyl hydroxylamine malonate, vanadyl hydroxylamine oxalate, vanadyl valine hydroxylamine, and vanadyl leucine hydroxylamine.
Coniferyl aldehyde or a combination of coniferous aldehyde and vanadium compounds protects nerve cells and maintains nerve cell function by inhibiting Aβ toxicity, inhibiting Tau protein hyperphosphorylation, restoring cell mitochondrial function, stimulating nerve cell regeneration, and other mechanisms. ; Vanadium compounds may protect nerve cell vitality and neurocognitive function in Alzheimer’s disease, diabetes and ischemic stroke model animals by regulating glucose metabolism in brain nerve cells and stimulating nerve cell regeneration. Coniferyl aldehyde and vanadium compounds in food ingredients The combination could also be developed into a drug to prevent Alzheimer’s disease.
Application report 2 of bis(pyridine-2-carboxylic acid) vanadyl(IV),
CN201610820080.4 reports a special capsule for diabetic patients. The ingredients of the capsule include Gymnema leaf extract, berberine, magnesium L-aspartate, selenoprotein, bis(pyridine-2-carboxylic acid) oxygen Vanadium(IV), Zinc Gluconate, Barnabas, White Leaf Extract, Garcinia Cambogia Extract, Momordica Momordica Extract, Fenugreek Extract. Also included are methods for producing the capsules. Starting from the sugar intake link, glucose digestion and absorption link, glucose transportation link and glucose utilization link of diabetic patients, the intestinal flora is adjusted at the same time to reduce blood lipids and achieve the effect of treating diabetes.
References
[1] [Invented in China, authorized by China] CN201611231409.X Use of coniferous aldehyde or coniferous aldehyde and vanadium compound composition for preventing and treating neurodegenerative diseases
[2]CN201610820080.4 A capsule for diabetic patients and its production method
