Overview[1][2]
Adenosine triphosphate disodium is a derivative of nucleotides and a coenzyme that participates in the metabolism of fat, protein, sugar, nucleic acid, and nucleotides in the body. Adenosine triphosphate disodium can penetrate the blood-brain barrier, improve the stability and reconstruction ability of nerve cell membrane structures, and promote nerve growth. Clinically used for auxiliary treatment of progressive muscle atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, cardiomyopathy, hepatitis, etc.
Indications[1][2]
1. It is suitable for the prevention and treatment of vitamin B6 deficiency and isoniazid poisoning; it can also be used for vomiting caused by pregnancy, radiation sickness and anti-cancer drugs, seborrheic dermatitis, etc.
2. Total parenteral nutrition and vitamin B6 supplementation when malnutrition and progressive weight loss occur due to insufficient intake.
3. The following conditions increase the demand for vitamin B6: pregnancy and lactation, hyperthyroidism, burns, long-term chronic infection, fever, inborn errors of metabolism (cystathionuria, hypertension) Oxalates, homocystinuria, xanthine aciduria), congestive heart failure, long-term hemodialysis, malabsorption syndromes with hepatobiliary diseases (such as alcoholism with cirrhosis), intestinal diseases (chylo diarrhea, tropical sprue, localized enteritis, persistent diarrhea), and after gastrectomy.
4. Neonatal hereditary vitamin B6 dependence syndrome.
Efficacy and role[2]
Adenosine triphosphate disodium is clinically used for various diseases caused by tissue damage and decreased cell enzyme activity. Such as heart failure, myocarditis, myocardial infarction, cerebral arteriosclerosis, coronary atherosclerosis, progressive muscular atrophy, sequelae of cerebral hemorrhage, acute and chronic hepatitis, liver cirrhosis and hearing impairment, etc.
Adenosine triphosphate disodium is a coenzyme drug used for the treatment of progressive muscle atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, myocardial disease and hepatitis.
Pharmacology and Toxicology[2][3]
Adenosine triphosphate disodium is a coenzyme. Adenosine triphosphate disodium is a nucleotide derivative that participates in the metabolism of fat, protein, sugar, nucleic acid and nucleotides in the body. When energy is needed for absorption, secretion, muscle contraction, and biochemical synthesis reactions in the body, adenosine triphosphate is decomposed into adenosine diphosphate and phosphate groups, and energy is released at the same time. Adenosine triphosphate disodium can penetrate the blood-cerebrospinal fluid barrier, improve the stability and reconstruction ability of nerve cell membrane structures, and promote the regrowth of neurites.
Pharmacokinetics [4]
Adenosine triphosphate disodium and pentose can synthesize nucleic acids under the action of enzymes in the body; and phospholipid cholamine can synthesize cephalin and cytidine monophosphate under the action of transcytidylase. This product is mainly metabolized by the liver in the body, and a small amount is excreted by kidney metabolism.
Usage and dosage[2][3] [4]
Subcutaneous injection, intramuscular or intravenous injection, 50 mg to 100 mg once a day. When used for detoxification of cycloserine poisoning, 300mg or more per day. When used to detoxify isoniazid poisoning, give 1g of vitamin B6 intravenously for every 1g of isoniazid.
Adverse reactions[3] [4]
Contraindications for adenosine triphosphate disodium tablets mainly include patients who are allergic to the ingredients of this product and should not use this product, and patients who are in the early stages of cerebral hemorrhage should not use this product. At present, the clinical safety of use for children, pregnant women and lactating women is not clear, so it is recommended that the above groups use it with caution under the guidance of professional doctors.
Adenosine triphosphate disodium tablets are coenzyme drugs and are mainly used clinically for the auxiliary treatment of progressive muscle atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, myocardial disease and hepatitis. Patients have few adverse reactions while taking this product, and a few patients may experience mild gastrointestinal discomfort.
