Overview of the free base application of 2-hydrazinopyridine dihydrochloride
2-Hydrazinepyridine dihydrochloride is an organic intermediate and is the hydrochloride form of 2-hydrazinepyridine.
Free base application of 2-hydrazinopyridine dihydrochloride Free base application
CN201811630637.3 reports a kind of N-butyl-4-hydroxy-1,8-naphthalenedicarboximide-3-carbaldehyde-(2-pyridine)hydrazone and its application; the preparation method is: N-butyl-4-hydroxy-1,8-naphthalenedicarboximide-3-carbaldehyde and 2-hydrazinopyridine are dissolved in methanol, heated to reflux, cooled to the end of the reaction, and obtained by suction filtration and washing with methanol;
The present invention also provides N-butyl-4-hydroxy-1,8-naphthalenedicarboximide-3-carboxaldehyde-(2-pyridine)hydrazone in Fe3+ and quantitative detection methods and the application of fluorescence imaging of Fe3+ in cells; N-butyl-4-hydroxy-1,8-naphthalenedicarboximide-3-carbaldehyde of the present invention The synthesis method of -(2-pyridine)hydrazone is simple; it can be used as a fluorescent probe for Fe3+ detection. It has good selectivity for Fe3+ and is not affected by other Due to the interference of coexisting cations, the detection sensitivity is high. At the same time, the color changes from pink to light yellow, which can be recognized with the naked eye. The operation method is simple, low cost, fast and convenient; and the fluorescence of Fe3+ is achieved in cells. imaging, so it has potential application value in sensor development.
CN201810229588.6 discloses a [1,2,4]-triazolo[4,3-a]pyridine compound and its synthesis method. The general structural formula of the compound is as shown in formula (Ⅰ),
Wherein R1 is selected from aryl, heterocyclyl, R2 is selected from hydrogen, alkyl, alkoxy, halogen or aryl. This synthesis method uses α-keto acid and 2-hydrazopyridine as raw materials, KI as the catalyst, Na2CO3 as the base, TBHP as the oxidant, and 1,4- Dioxane is used as the solvent, and [1,2,4]-triazolo[4,3-a]pyridine compounds are generated after a series of series cyclization and decarboxylation aromatization. The invention is prepared from barium borate carbonate under transition metal-free conditions, and has the advantages of efficient and rapid reaction, mild conditions, simple and easy-to-obtain substrates, wide applicability, short reaction time, high yield, etc., and simultaneously reacts The post-processing is also very simple, which reduces the harm to experimental operators. It is environmentally friendly and meets the requirements of green chemistry.
