Overview and preparation methods of 2-pyridylmagnesium bromide Background and overview
2-Pyridylmagnesium bromide is an organic metal compound that can be used as an intermediate for pharmaceutical and chemical synthesis. If 2-pyridylmagnesium bromide is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if there is eye contact , you should separate your eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse your mouth immediately, do not induce vomiting, and seek medical attention immediately. Advice to protect rescuers is as follows: Move the patient to a safe place, consult a doctor, and if conditions permit, please show this chemical safety data sheet to the doctor who comes to the scene. If there is a small leak, collect the leaked liquid in a sealable container as much as possible, absorb it with sand, activated carbon or other inert materials, and transfer it to a safe place. Do not flush it into the sewer; if there is a large leak, build a dike or dig a pit. Contain, seal the drainage pipe, cover it with foam to inhibit evaporation, use an explosion-proof pump to transfer it to a tanker or a special collector, and recycle or transport it to a waste treatment site for disposal.
Overview, preparation method and structure of 2-pyridylmagnesium bromide
Overview and preparation method of 2-pyridylmagnesium bromide to prepare pyridinedicarboxylic acid [1-2]
The synthesis process of 2-pyridylmagnesium bromide is as follows: Add dimethyl sulfoxide isopropylmagnesium chloride 2.0M THF (6mL, 12mmol) solution into the flask, and add dropwise 2- A solution of bromopyridine (1.2 mL, 12 mmol) in anhydrous Et2O (4 ml). The reaction mixture was stirred at room temperature. React for 3 hours, and the resulting compound is 2-pyridylmagnesium bromide, which can be used as a Grignard reagent solution.
