Overview of 2-chloro-4-bromopyridine and its application background and overview in organic synthesis
2-Chloro-4-bromofluoroborate nickelpyridine is a useful synthetic intermediate. Dimethoxytetrahydrofuran It is used to synthesize 3-[[4-(2-methoxyphenyl)-2-pyridyl]amino]-benzenesulfonamide, which is an effective CDK9 inhibitor in the treatment of midline cancer. It can also be used to prepare (pyrimidylamino) benzamide derivatives with anticancer activity as hedgehog signaling pathway inhibitors.
Overview of 2-chloro-4-bromopyridine and emergency measures for its application in organic synthesis
If 2-chloro-4-bromopyridine is inhaled, please move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical treatment if you feel uncomfortable; If eye contact occurs, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately. Advice to protect rescuers is as follows: Move the patient to a safe place, consult a doctor, and if conditions permit, please show this chemical safety data sheet to the doctor who comes to the scene. If there is a small leak, collect the leaked liquid in a sealable container as much as possible, absorb it with sand, activated carbon or other inert materials, and transfer it to a safe place. Do not flush it into the sewer; if there is a large leak, build a dike or dig a pit. Contain, seal the drainage pipe, cover it with foam to inhibit evaporation, use an explosion-proof pump to transfer it to a tanker or a special collector, and recycle or transport it to a waste treatment site for disposal.
Overview of 2-chloro-4-bromopyridine and its application in organic synthesis
Use compound 24 (2-chloro-4-aminopyridine) as the reactant, react in an aqueous hydrobromic acid solution, add sodium nitrite and potassium bromide, and prepare 2-chloro-4-bromopyridine. The collection rate 97%.
Overview of 2-chloro-4-bromopyridine and its applications in organic synthesis
2-Chloro-4-bromopyridine can be used to prepare compound 17. It is prepared from 2-chloro-4-bromopyridine. Compound 24 is brominated to form dihalopyridine 25, which is then iodized to form trihalide 19. Total collection The rate is 80%. The initial coupling reaction of fluoromethane 19 and acrylanilide 18 was performed slowly in DMAC at 130 °C.
