Polyurethane|Medical polyurethane cotton ball and its preparation method
Abstract
The invention provides a medical polyurethane cotton ball and its preparation method and application. The medical polyurethane cotton ball is made by cutting a polyurethane sponge. The polyurethane sponge is made of polyether triol, toluene diisocyanate, water and cross-linking agent. It is made by foaming with auxiliary agents. The medical polyurethane cotton ball provided by the invention has the advantages of simple preparation method, no biological toxicity, fast liquid absorption speed, large liquid absorption capacity, high liquid extrusion rate, no crumbs or lint when applied, certain resilience, and easy storage. . Polyurethane cotton balls can be used directly in a dry state. They can quickly absorb a large amount of wound exudate, reducing operating time and the amount of cotton balls used. They can be used after absorbing iodophor or medical alcohol, and they can cover a large area at one time. The application operation can reduce the frequency of replacement of cotton balls and improve the application efficiency. The medical polyurethane cotton ball provided by the invention is skin-friendly, soft and highly comfortable in both dry and wet states, and can effectively reduce irritation to the skin and wounds.
Technical fields
The present invention belongs to the technical field of medical materials, and in particular relates to a polyurethane sponge and its preparation method and application. Specifically, it is a medical polyurethane cotton ball and its preparation method and application.
Background technology
Medical cotton balls are a common medical product, which are divided into sterile supplied medical cotton balls and non-sterile supplied medical cotton balls. Sterile supplied medical cotton balls are widely used in medical institution care, examinations, surgeries and daily disinfection.
Currently, medical cotton balls are made of sterilized absorbent cotton, which is not only prone to insect infestation, deterioration, and inconvenient for long-term storage, but also has poor liquid absorption performance and low liquid extrusion rate, resulting in dry medical absorbent cotton. The ball cannot absorb a large amount of wound exudate at one time during debridement, which increases the operation time and the amount of medical absorbent cotton balls used. Similarly, alcohol or iodophor absorbent cotton balls have a small amount of medicine and cannot complete a large area at one time. The smearing operation reduces the smearing efficiency and increases the frequency of replacement of medical absorbent cotton balls and the amount of medicinal solution. In addition, medical absorbent cotton balls have no elasticity. As a temporary filling for oral examination and repair, they are inconvenient for doctors to use and provide poor patient experience. At the same time, because the texture of medical absorbent cotton balls is not soft enough to be skin-friendly, cotton wadding is easy to remain during use, resulting in poor comfort when treating wounds and easy irritation of the wound.
Example 1
Under nitrogen protection, add 100.00g of anhydrous polyether triol (ethylene oxide:propylene oxide is 30:70, number average molecular weight is 6000, American Dow’s 6001 model polyol) , add 20.19g of toluene diisocyanate (a mixture of 80% mass percentage of 2,4-toluene diisocyanate and 20% mass percentage of 2,6-toluene diisocyanate), stir and react at 70°C until NCO The value is stable, and polyurethane cotton ball material A is obtained;
Place 100.00g deionized water, 0.50g trimethylolpropane, 33.87g glycerol, 13.92g polymeric siloxane (Y-10366), 7.16g aliphatic Mix polyoxyethylene (15) ether and 4.78g of sorbitan fatty acid ester evenly at 15°C to obtain polyurethane cotton ball material B;
Make 50.00g of the above-mentioned material A and 56.00g of material B freely foam by mechanical stirring at 20°C, with a rotation speed of 1500rpm and a time of 15s. After foaming, a medical polyurethane cotton ball material is obtained;
Take out the formed medical polyurethane cotton ball material from the mold, place it in a 60°C oven for heat treatment for 4 hours, then sterilize it with ethylene oxide, and place it in a sterile environment for 14 days before performing a performance test.
The product prepared in Example 1 was cut into spheres with a mass of 0.5g (as shown in Figure 1) for absorbing blood and tissue fluid exuded from the wound.
Example 2
Under nitrogen protection, add 100.00g of anhydrous polyether triol (ethylene oxide:propylene oxide is 40:60, number average molecular weight is 5000, American Dow’s 4701 model polyol) , add 32.30g of toluene diisocyanate (100% mass percentage of 2,4-toluene diisocyanate), and stir at 80°C.p-content/uploads/2023/05/1684378147119-768×470.png 768w, https://www.bdma.com.cn/wp-content/uploads/2023/05/1684378147119-220×135.png 220w” sizes=”( max-width: 826px) 100vw, 826px” title=”Polyurethane| Medical polyurethane cotton ball and its preparation method illustration 2″ alt=”Polyurethane| Medical polyurethane cotton ball and its preparation method illustration 2″ />
Under nitrogen protection, add 100.00g of anhydrous polyether triol (ethylene oxide:propylene oxide is 30:70, number average molecular weight is 5000, EP of Shandong Blue Star Dongda Chemical Co., Ltd. -3600 model polyol), add 28.09g of toluene diisocyanate (a mixture of 80% mass percentage of 2,4-toluene diisocyanate and 20% mass percentage of 2,6-toluene diisocyanate), Stir the reaction at 85°C until the NCO value is stable to obtain polyurethane cotton ball material A;
Put 100.00g of deionized water, 19.85g of glycerin, 22.48g of oxypropylene oxyethylene propylene glycol ether, 10.03g of polyoxyethylene ether, and 3.30g of sorbitan fatty acid The ester and 1.15g of polyoxyethylene sorbitan fatty acid ester were mixed evenly at 35°C to obtain polyurethane cotton ball material B;
Foam 50.00g of the above-mentioned material A and 72.00g of material B in a foaming machine at 45°C. After foaming, a medical polyurethane cotton ball material is obtained;
Take out the formed medical polyurethane cotton ball material from the mold, place it in a 100°C oven for heat treatment for 2 hours, then sterilize it with ethylene oxide, and then place it in a sterile environment for 14 days before performing a performance test.
The product prepared in Example 6 is cut into a cylinder with a length of 2.0 to 5.0 cm and a diameter of 0.7 cm (as shown in Figure 6), and is used as a temporary filling during oral examination and repair.
