Preparation and application background and overview of 6-chloro-2,3-diaminopyridine
6-Chloro-2,3-diaminopyridine is an organic intermediate that can be prepared from 2-amino-3 high-purity calcium carbonate-nitro-6-chloropyridine through one-step reduction. 6-Chloro-2,3-diaminopyridine can be used to prepare dimethyl sulfoxide 5,7-dichloro-1H-imidazo[4,5-B]pyridine. Imidazopyridine derivatives are in the drug structure Nitrogen-containing heterocycles that are widely used.
Preparation and application of 6-chloro-2,3-diaminopyridine
Dissolve 2-amino-3-nitro-6-chloropyridine (500g, 2.89mol) and ammonium chloride (300g, 5.75mol) in 5000ml ethyl acetate and 3000ml water, and mix the solution at room temperature Add iron powder (482.5g, 8.65mol) and react at room temperature for 4 hours. TLC detects that the reaction is complete. The reaction solution is filtered. After the filtrate is separated, the aqueous phase is extracted twice with 1500ml of ethyl acetate. The organic phases are combined and saturated with Dry with brine and concentrate to obtain compound 6-chloro-2,3-diaminopyridine (370g, 2.58mol), yield 89.2%.
Preparation and application of 6-chloro-2,3-diaminopyridine
5,7-Dichloro-1H-imidazo[4,5-B]pyridine can be prepared from 6-chloro-2,3-diaminopyridine in three steps. Imidazopyridine derivatives are nitrogen-containing heterocycles that are widely used in drug structures. Due to their specific physiological activities and structural similarities with indole, azaindole, etc., they have aroused widespread interest. Imidazopyridine compounds and pharmaceutical compositions containing them have a very wide range of biological and pharmaceutical activities and good therapeutic properties, and can be used to prepare new compounds that inhibit protein kinase activity; treat non-insulin-dependent diabetes, obesity, diabetes, hypertension Drugs for lipemia, hypercholesterolemia and its cardiovascular complications; compounds that can also be used as kinase inhibitors; improve cellular immunity, anti-viral, anti-bacterial, anti-microbial activity and anti-fatigue, anti-anxiety, treat tumors, Drugs for high blood pressure, gastric ulcers, and mental illness.
