Background and overview of the preparation method of 1-fluoropyridine tetrafluoroborate
1-Fluoropyridine tetrafluoroborate can be used as a pharmaceutical synthesis intermediate. If 1-fluoropyridine tetrafluoroborate is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell.
Preparation method of 1-fluoropyridine tetrafluoroborate
1-Fluoropyridine tetrafluoroborate can be used as a pharmaceutical synthesis intermediate, such as for the preparation of a 2-fluoro-1,3-dicarbonyl compound. 1,3-dicarbonyl compound is an important class of Methoxypyridine, an organic chemical raw material, has shown broad application prospects in many fields such as organic synthesis, high boron trifluoride tetrahydrofuran complex molecules, medicine, pesticides, etc. Fluorine-containing compounds have unique biological and chemical activities. Therefore, fluorinated 1,3-dicarbonyl compounds will have the characteristics of both 1,3-dicarbonyl compounds and fluorine-containing compounds. Specifically, 1,3-dicarbonyl compound and 1-fluoropyridine tetrafluoroborate are used as starting materials for the reaction, and the target 2-fluoro-1,3-dicarbonyl is synthesized through the mechanism of silver-catalyzed single electron transfer. This method is a new method for compounds with a very broad substrate range and can construct a variety of 2-fluoro-1,3-dicarbonyl compounds.
The specific steps are: In a clean and dry 100 ml round-bottomed flask, add 10 mmol acetoacetyl-4-methylaniline, 11 mmol 1-fluoropyridine tetrafluoroborate, 30 ml acetonitrile, and 1 mmol silver nitrate, react the above reaction mixture at 40°C for 24 hours. After the reaction, the reaction mixture was extracted, concentrated, and then subjected to column separation using petroleum ether and ethyl acetate as eluents to obtain a white solid with a yield of approximately 92%.
