Background and overview of the preparation method of boron trifluoride tetrahydrofuran
Boron trifluoride and tetrahydrofuran can be used in organic synthesis. The current production technology in Japan and the United States uses boron trifluoride and tetrahydrofuran liquids to react, and then uses a magnesium drum to dry to obtain flaky boron trifluoride tetrahydrofuran. This reaction is an exothermic reaction, the reaction temperature is difficult to control, and the product drying cost is high. high. Therefore, a new production process needs to be provided to solve the above problems.
Preparation method and application of boron trifluoride tetrahydrofuran
Boron trifluoride and tetrahydrofuran can be used to synthesize organic sodium bicarbonate. Application examples are as follows:
1) Used to prepare a diarylmethane derivative. This method uses various benzyl alcohols or benzyl esters as benzylation reagents, boron trifluoride ether or boron trifluoride tetrahydrofuran as reaction reagents, various aromatic hydrocarbons as raw materials and also as solvents, through one-step aromatic hydrocarbon benzylation reaction and concentration, Purified finished product. This method has the characteristics of mild reaction conditions, low requirements for production equipment, simple process, safe preparation and reaction production, easy operation, easy availability of raw materials, short reaction time, high efficiency, simple product purification, etc.; the method of the present invention can produce high-yield preparations , a variety of diarylmethane derivative products of good quality. The method of the present invention can be widely used in the industrial production of diarylmethane derivatives, and the products prepared by the method of the present invention can be widely used as synthetic precursors for pharmaceutical synthesis intermediates, aromatics, spices, polycarbonate resins, dyes, etc. , market application prospects are good.
2) To prepare a kind of hydroxytyrosol, stir the solvent, 3,4-dimethoxyphenylethyl alcohol and aluminum triiodide evenly, add boron trifluoride tetrahydrofuran or boron trifluoride ethyl ether, raise the temperature and reflux , after the reaction is complete, lower to room temperature, filter, add activated carbon to the filtrate, filter again, recover the filtrate to dryness to obtain a light yellow oily residue, then add methylene chloride, reflux, lower to room temperature and beat, filter to obtain White powder solid hydroxytyrosol. The invention avoids the complicated operations of multiple extractions in the water phase by conventional methods, and the product content is more than 98%, which far exceeds the product quality of the prior art.
Preparation method of boron trifluoride and tetrahydrofuranSodium perborate tetrahydrate
The production process of boron trifluoride tetrahydrofuran includes the following steps: slowly drop tetrahydrofuran into the caustic soda kettle, absorb water to generate tetrahydrofuran vapor, introduce tetrahydrofuran vapor into the complexing device, and simultaneously introduce boron trifluoride gas for processing For the complexation reaction, the mass ratio of tetrahydrofuran and boron trifluoride gas is 1:2, the temperature is controlled between 30°, and the reaction time is 2 hours; after drying, boron trifluoride tetrahydrofuran is obtained.
