What are the differences between HOBT condensation agent and TBTU? The difference between condensation agents
1. HBTU and TBTU are enhanced versions of HOBT condensation agents with better effects and generate HOBT after reaction.
2. The condensation effect of TBTU is slightly better.
What are the differences between HOBT condensation agent and TBTU? 1. HOBT condensation agent:
HOBT condensation agent is a commonly used amide condensation agent, which is a condensation agent that forms amide from organic acids and organic amines.
The structure of HOBT condensation agent is a benzotriazole structure, so it has water solubility but not high, that is, it is slightly soluble. The reaction process generally does not use aqueous phase, and generally uses non-aqueous solvents, such as dichloromethane. kind of solvent.
HOBT condensation agent methylpyridine has a triazole structure, so the inorganic acid aqueous solution can be dissolved. In addition to formic acid and acetic acid, organic acids can also be used as solvents. Most of the other organic acids are solid at room temperature and are generally not solvents.
What are the differences between HOBT condensing agent and TBTU? 2. TBTU
Among many coupling agents, urea ionic peptide condensation agent TBTU has a wide range of applications and is cost-effective. Urea ionic polypeptide condensing agent is a multifunctional reagent for activating carboxylic acid. They react and combine amino acids with amines in one step, without the need for pre-activation of the acid. Their advantages include convenient and practical reaction procedures, rapid in situ activation, small side reactions, commercial availability, stability, solubility in a wide range of solvents including water and easy removal of coupling by-products. Since urea ionic peptide condensing agents have very good practicality, developing their diversified applications has become a new research hotspot.
1. Using TBTU as the coupling agent, acetonitrile as the solvent, different sulfonic acids and different oximes were synthesized with good yields at 50°C. The advantages of this method are simple reaction process, no harm to the environment and simple post-processing.
2. Using TBTU as coupling agent, acetonitrile as solvent, carboxylic acid and heterocyclic secondary amines such as indole, imidazole, etc., can synthesize a sequence of carboxylic acid heterocyclic secondary amines with good yield at normal temperature and sodium carbonate temperature. Amine compounds. The advantages of this method are that the by-products cause little environmental pollution, the products are easy to separate, and the reaction process is simple.
3. Using TBTU as the coupling agent and acetonitrile as the solvent, carboxylic acid and chemical compounds, amines or alcohols are used to synthesize a sequence of urea and carbamate compounds. This method uses a one-pot method, which is not only convenient to operate, but also has high yield.
